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Tirzepatide activates both GLP-1 and GIP receptors, engaging 40% more metabolic pathways than semaglutide alone

GLP-1-based therapies should be used with caution in pregnancy or breastfeeding, and the risk of hypoglycaemia is increased when these agents are used alongside insulin or sulfonylureas

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Some protocols recommend taking it on an empty stomach, first thing in the morning, to maximize absorption and align with the natural fasting state when lipolysis is already elevated

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